miR-21、miR-125b与舌鳞状细胞癌患者预后生存的关系

目的 研究miR-21、miR-125b与舌鳞状细胞癌患者预后生存的关系.方法 选取86例舌鳞状细胞癌患者手术切除的癌组织与对应的癌旁正常组织,分别测定其组织中miR-21、miR-125b表达量.患者随访半年,分析miR-21、miR125b表达与患者预后生存的关系.结果 舌鳞状细胞癌组织中miR-21、miR125...

Kaplan-Meier Analysis of Prognostic Value of miR-21 and miR-125b in Patients with Tongue Squamous Cell Carcinoma

Objective To investigate the prognostic value of miR-21 and miR-125 b in patients with tongue squamous cell carcinoma based on Kaplan-Meier analysis.Methods 86 cases of tongue squamous cell carcinoma were selected, and the expression levels of miR-21 and miR-125 b in surgically resected cancer tissues and adjacent normal tissues were detected respectively.Results The expression of miR-21 and miR125 b in tongue squamous cell carcinoma tissues was significantly higher than that in adjacent normal tissues(P<0.05).The expression of miR-21 and miR125 b in tongue squamous cell carcinoma was not related to gender and age(P>0.05),but was related to the degree of tissue differentiation, lymphatic metastasis and clinical stage(P<0.05).The half-year follow-up results showed that 17 patients died and 69 survived.Kaplan-Meier survival analysis showed that patients with high expression of miR-21 and miR125 b had low survival rate.Cox proportional hazard regression model analysis showed that elevated expression of miR-21 and miR125 b, cervical lymph node metastasis, and clinical stage of Ⅲ~Ⅳ were the prognostic factors of patients with tongue squamous cell carcinoma(P<0.05).Conclusion The expression of miR-21 and miR-125 b in tongue squamous cell carcinoma tissue is elevated, and related to the degree of tissue differentiation, cervical lymph node metastasis and clinical stage.The two indicators are risk factors that affect the prognosis, which can be used as clinical predictors of prognostic survival.