分析阻塞性睡眠呼吸暂停低通气综合征与甲状腺功能减退症的关系

目的:分析阻塞性睡眠呼吸暂停低通气综合征(Obstructive Sleep Apnea Hypopnea Syndrome,OSAHS)与甲状腺功能减退症的关系.方法:选取2020年1月至2020年9月蚌埠市第一人民医院内分泌科收治的OSAHS患者60例作为研究对象,按照是否合并甲状腺功能减退分为对照组和观察组,其中...

To Analyze the Relationship Between Obstructive Sleep Apnea Hypopnea Syndrome and Hypothyroidism

Objective:To investigate the relationship between Obstructive Sleep Apnea Hypopnea Syndrome(OSAHS)and hypothyroidism.Methods:A total of 60 patients with OSAHS from January 2020 to September 2020 in the first people′s hospital of Bengbu endocrinology were selected as the research objects,according to whether the merger decreased thyroid can be divided into control group and observation group,31 cases in the control group,unincorporated hypothyroidism patients,29 cases in the observation group,combination of hypothyroidism.Meanwhile,patients between the two groups were given symptomatic comprehensive treatment,patients with severe OSAHS were given continuous positive airway pressure(CPAP),and the levels of serum free thyroxine(FT4),total thyroxine(TT4)and thyroid-stimulating growth hormone(TSH)were observed before and after treatment.The Apnea Hypopnea Index(AHI),average blood oxygen saturation(MSO₂)and lowest blood oxygen saturation(LSO₂)of the two groups were observed.Meanwhile,the positive rates of anti-thyroglobulin antibody(TgAb)and anti-thyroperoxidase antibody(TPOAb)between 2 groups were compared.Results:After treatment,the levels of thyroid hormone FT4,TT4 and TSH in control group were not significantly different from those before treatment(P>0.05).The levels of FT4 and TT4 in the observation group were higher than before treatment,and the TSH level was lower than before treatment,with statistical significance(P<0.05).After treatment,FT4 and TT4 levels in the observation group were significantly higher than those in the control group,while TSH levels were significantly lower than those in the control group,with statistical significance(P<0.05).After treatment,AHI index of control group was significantly decreased,MSO₂ and LSO₂ were significantly increased,the differences were statistically significant(P<0.05).After treatment,MSO₂ and LSO₂ in observation group were significantly increased,AHI index was significantly decreased,the differences were statistically significant(P<0.05).After treatment,the AHI index of observation group was significantly lower than that of control group,the difference was statistically significant(P<0.05).MSO₂ and LSO₂ were similar to the control group,but there was no statistical significance(P>0.05).After treatment,the positive rate of TgAb and TPOAb in the observation group was significantly higher than that in the control group,and the difference between the two groups was statistically significant(P<0.05).Conclusion:There are more patients with hypothyroidism in OSAHS,Early diagnosis and comprehensive treatment can effectively improve the prognosis of OSA.