| 血七胶囊质量标准提高研究 |
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| 引用本文： | 陆才洋,汪霞. 血七胶囊质量标准提高研究[J]. 海峡药学, 2020, 32(6): 71-73. DOI: 10.3969/j.issn.1006-3765.2020.06.024 |
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| 作者姓名： | 陆才洋 汪霞 |
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| 作者单位： | 湖南省药品审评认证与不良反应监测中心,湖南长沙410013,娄底市食品药品检验检测所,湖南娄底417000 |
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| 摘 要： | 目的提高血七胶囊的质量标准。方法采用高效液相色谱法(HPLC),色谱柱为Thermoscientific C 18,流动相为乙腈-水(37∶63),流速1.0mL·min^-1,检测波长278nm,同时测定君药龙血竭中龙血素A、龙血素B的含量。结果龙血素A在16.176~129.408ng范围内线性关系良好(r=1.000),平均加样回收率100.7%,RSD为1.6%;龙血素B在28.598~228.784ng范围内线性关系良好(r=1.000),平均加样回收率101.5%,RSD为1.1%。结论本实验建立的方法具有专属、简便、准确、可重复的特点,增强了血七胶囊的质量可控性,提高了血七胶囊的质量标准。
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| 关 键 词： | 龙血素A 龙血素B 血七胶囊 质量标准 |
Improvement of Quality Standard of Xueqi Capsules |
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| LU Cai-yang,WANG Xia. Improvement of Quality Standard of Xueqi Capsules[J]. Strait Pharmaceutical Journal, 2020, 32(6): 71-73. DOI: 10.3969/j.issn.1006-3765.2020.06.024 |
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| Authors: | LU Cai-yang WANG Xia |
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| Affiliation: | (Hunan Provincial Center for Drug Evaluation,Accreditation and Adverse Drug Reaction Monitoring,Changsha 410013,China;Loudi Institute for Food and Drug Inspection&Testing,Loudi 417000,China) |
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| Abstract: | OBJECTIVE To improve the quality standard of Xueqi Capsules.METHODS By HPLC,A Thermoscientific C 18 column was used,with mobile phase of Acetonitrile-water(37∶63).The flow rate was 1.0mL·min^-1 and the detective wavelength was 278nm.Loureirin A、Loureirin B in Dragon′s Blood were simultaneously determined.RESULTS The linear range of Loureirin A was 16.176-129.408ng(r=1.000),the average recovery was 100.7%,with RSD of 1.6%.The linear range of Loureirin B was 28.598-228.784ng(r=1.000),the average recovery was 101.5%,with RSD of 1.1%.CONCLUSION The method is specific,simple,accurate and repeatable.The quality controllability of Xueqi Capsules is enhanced and the quality standard is improved. |
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| Keywords: | Loureirin A Loureirin B Xueqi Capsules Quality standard |
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