| 膜型基质金属蛋白酶-1在肿瘤中的作用 |
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| 引用本文： | 罗先道,曾妍,杨磊. 膜型基质金属蛋白酶-1在肿瘤中的作用[J]. 陕西肿瘤医学, 2009, 17(10): 2005-2008 |
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| 作者姓名： | 罗先道 曾妍 杨磊 |
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| 作者单位： | 石河子大学新疆地方与民族高发病省部共建重点实验室,新疆石河子832002 |
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| 基金项目： | 【基金项目】国际科技合作重点项目（2005DFA30780）;教育部科学研究重大项目（206166） |
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| 摘 要： | 膜型基质金属蛋白酶（membrane—type matrix metalloproteinase，MT—MMP）是一类基质金属蛋白酶（matrix metalloproteinases，MMPs）家族的新成员，膜型基质金属蛋白酶-1（MT1-MMP／MMP14）是第一个鉴别出的膜型基质金属蛋白酶，它直接或间接降解细胞外基质中的多种成分，通过调节多种细胞效应分子影响肿瘤细胞的增殖和凋亡，细胞迁移，肿瘤细胞的浸润、转移以及血管生成等过程，在肿瘤的发生发展过程中有重要作用。
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| 关 键 词： | 膜型-1基质金属蛋白酶 细胞外基质降解 肿瘤转移 血管生成 |
The role of membrane -type 1 matrix metalloproteinase in tumor |
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| LUO Xian - dao,ZENG Yan,YANG Lei. The role of membrane -type 1 matrix metalloproteinase in tumor[J]. Shaanxi Oncology Medicine, 2009, 17(10): 2005-2008 |
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| Authors: | LUO Xian - dao ZENG Yan YANG Lei |
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| Affiliation: | (Key Laboratory of Xinjiang Endemic and Ethnic Diseases Shihezi University,Xinjiang Shihezi 832002, China. ) |
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| Abstract: | Membrane -type matrix metalloproteinase （MT- MMP）was a new member of matrix metalloproteinases （MMPs） family,and membrane -type 1 matrix metalloproteinase was the first membrane -type matrix metalloproteinase to be identified. It can directly or indirectly cause many components of the extracellular matrix degradation, and it has an impact on the process of tumor cells proliferation, apoptosis, migration, infiltration, transffering, and angiogenesis through regulating many kinds of cellular effector molecules. It plays an important role in the process of tumor＇s occurrence and development. |
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| Keywords: | membrane - typel matrix metalloproteinase extracellular matrix degradation tumor metastasis angiogenesis |
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