| 上皮性卵巢肿瘤组织中MMP2和MMP9的表达及临床意义 |
| |
| 引用本文： | 胡洁.上皮性卵巢肿瘤组织中MMP2和MMP9的表达及临床意义[J].中国中医药现代远程教育,2011,9(1):208-210. |
| |
| 作者姓名： | 胡洁 |
| |
| 作者单位： | 吉林省长春市妇产科医院,130042 |
| |
| 摘 要： | 目的研究基质金属蛋白酶(MMP2和MMP9)在上皮性卵巢肿瘤组织中的表达及临床意义。方法应用免疫组化EnVision法检测38例上皮性卵巢癌(A组)、20例交界性上皮性卵巢肿瘤(B组)、20例良性上皮性卵巢肿瘤(C组)和20例正常卵巢组织(D组)中MMP2和MMP9的表达和预后。结果 MMP2和MMP9在上皮性卵巢癌中的阳性率分别为94.7%和92.1%,显著高于良性卵巢肿瘤(40%)和正常卵巢(40%和50%),A组中的强阳性率(73.7%和78.9%)显著高于B组(27.2%和31.8%)、C组(5%)和D组(10%)(P<0.05);晚期上皮性卵巢癌中的强阳性率(94.4%和88.9%)显著高于早期的强阳性率(40%和45%)(P<0.05);中低分化(G2～G3级)上皮性卵巢癌中的强阳性率(53.3%和40%)显著高于高分化(G1级)的强阳性率(12.5%)(P<0.05);有淋巴转移的上皮性卵巢癌中的强阳性率(94.7%和89.5%)显著高于无淋巴转移组的强阳性率(68.4%和73.7%)(P<0.05)。结论 MMP2和MMP9可能参与卵巢的正常生理功能,它的异常高表达在上皮性卵巢癌的浸润、转移和交界性上皮性卵巢肿瘤的复发中起了重要作用。
|
| 关 键 词： | 卵巢肿瘤 基质金属蛋白酶(MMP2和MMP9) 临床意义 |
Expression of MMP2 and MMP9 in Tissue of Epithelial Tumor of Ovary and its Clinical Significance |
| |
| Hu Jie.Expression of MMP2 and MMP9 in Tissue of Epithelial Tumor of Ovary and its Clinical Significance[J].Chinese Medicine Modern Distance Education of China,2011,9(1):208-210. |
| |
| Authors: | Hu Jie |
| |
| Institution: | Hu Jie(Changchun Obstetrics-Gynecology Hospital Jilin province 130042,China) |
| |
| Abstract: | Objective To study the expression of metalloproteinase(MMP2 and MMP9) in tissue of epithelial tumor of ovary,and to discuss its clinical significance. Methods Immunohistochemical staining(EnVision method) was used to detect the expression of MMP2 and MMP9 in 38 specimens of epithelial ovarian carcinomas(group A) ,20 epithelial borderline ovarian tumors(group B) ,20 epithelial benign ovarian tumors(group C) and 20 normal ovarian tissues(group D) . Results The positivity of MMP2 and MMP9 in group A(94.7% and ... |
| |
| Keywords: | IL-17 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
