Comparison of microarray-based RNA expression with ELISA-based protein determination of HER2, uPA and PAI-1 in tumour tissue of patients with breast cancer and relation to outcome |
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| Authors: | Isabell D. Witzel Karin Milde-Langosch Ralph M. Wirtz Claudia Roth Maike Ihnen Sven Mahner Christine Zu Eulenburg Fritz Jänicke Volkmar Müller |
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| Affiliation: | (1) Department of Gynecology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany;(2) Siemens Healthcare Diagnostics Products GmbH, Cologne, Germany;(3) Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; |
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| Abstract: | Purpose Prognostic and predictive markers in breast cancer are currently determined by single analysis of protein amounts. If RNA-based multi-gene analyses enter clinical practice, simultaneous determination of currently established markers like human epidermal growth factor receptor 2 (HER2), urokinase plasminogen activator (uPA) and its inhibitor (PAI-1) would represent an elegant simplification. To investigate the correlation between RNA and protein levels, we assessed HER2, uPA and PAI-1 in patients with breast cancer. In addition, we evaluated the influence of these factors on patient outcome. |
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