化痔片的抗炎镇痛及抗直肠溃疡作用

目的:考察化痔片的抗炎镇痛及抗直肠溃疡作用。方法:采用二甲苯涂耳致小鼠耳肿胀法,新鲜蛋清致大鼠后足踝关节肿胀法,醋酸致小鼠扭体法,小鼠热板致痛舔后足法,金黄色葡萄球菌合并外力损伤致家兔直肠溃疡法,考察化痔片的作用。结果:化痔片对二甲苯致小鼠的耳肿胀和新鲜蛋清致大鼠的足肿胀急性炎症有显著的抑制作用;对醋酸致小鼠扭体及热板致小鼠后足烫痛均有显著的镇痛作用;对金黄色葡萄球菌合并外力损伤致家兔直肠的溃疡有明显改善作用。结论:化痔片具有良好的抗炎、镇痛及抗直肠溃疡作用。

Anti-inflammatory,Analgesic and Relieving Rectal Ulceration Effects of the Eliminating Hemorrhoids Tablet

Objective:To find out the anti-inflammatory,analgesic,relieving carbuncle and promoting tissue regeneration of the Eliminating Hemorrhoids Tablet(EHT).Methods: Models of acute inflammatory reactions of xylene-induced mouse ear edema and paw edema induced by fresh egg white in rat were performed to study the anti-inflammatory effects of EHT.Methods of acetic acid-induced writhing and hot-plate test in mice were used to study the analgesic effects of EHT.And also pyogenic infection and ulcerateon of rectal mucosa in rabbits were produced by Staphylococcus aureus.Results: The results of the acute anti-inflammatory experiments showed that ear edema resulted from xylene in mice and paw edema induced by fresh egg white in rats were significantly inhibited by EHT;and EHT could produce obvious analgesic effect on pain caused by acetic acid stimulus and heating in mice.It could also clear away the pyogenic material and promote tissue regeneration.Conclusions: EHT has significant effect on inflammation and algesia.It can relieve carbuncle and promote tissue regeneration.