| NOD样受体在慢性阻塞性肺疾病中的研究进展 |
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| 引用本文： | 贾钦尧,陈绍平,李新胜,张文波,向小均,毛建. NOD样受体在慢性阻塞性肺疾病中的研究进展[J]. 国际呼吸杂志, 2014, 0(23): 1812-1816 |
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| 作者姓名： | 贾钦尧 陈绍平 李新胜 张文波 向小均 毛建 |
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| 作者单位： | 川北医学院附属医院呼吸内科,南充637000 |
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| 摘 要： | NOD样受体是细胞内模式识别受体中的一个重要家族，是抵抗病原体入侵第一道防线的重要组成部分，可以通过激活核因子wB和丝裂原活化蛋白激酶通道、自我吞噬和类型1干扰素应答的参与，引起大量促炎因子的产生，在COPD的发病和急性加重中发挥了重要作用。本文就NOD样受体存COPD中的研究进展作一综述。
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| 关 键 词： | 慢性阻塞性肺疾病 NOD样受体 |
Research progress of NOD-like receptors in the chronic obstructive pulmonary disease |
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| Affiliation: | Jia Qinyao , Chert Shaoping , Li Xinsheng , Zhang Wenbo , Xiang Xiaojun , Mao J ian.( Department of Respiratory Medicine, the Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China) |
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| Abstract: | NOD-like receptors is an important family of intracellular pattern recognition receptors and thc key component of the first defense against pathogen attacks,NOD-like receptors can induce the massive generation of proinflammatory factors through the activation of NF-kB and MAPK channels, autophagy and the participation of 1 IFN response. It has played an important role in the pathogenesis and acute exacerbation of chronic obstructive pulmonary disease. The review aimed to summarize the research progress of NOI〉like receptors in the COPD. |
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| Keywords: | Chronic obstructive pulmonary disease NOD-like receptors |
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