肌萎缩侧索硬化的神经电生理改变的临床意义

目的观察肌萎缩侧索硬化(ALS)的电生理改变,并对其临床意义作初步评价。方法已确诊的36例ALS患者常规进行针极肌电图、神经传导速度、重复频率刺激试验检查,并对其结果进行分析。结果ALS的EMG表现为广泛的神经源性损害,如运动时限延长、波幅增高、纤颤电位、巨大电位等。小部分患者可出现感觉传导速度和运动传导速度减慢。部分患者存在重复频率刺激试验异常。结论神经电生理检查是辅助诊断的重要手段,并对了解其病生理机制有一定帮助。

The clinical significance of neural electrical pathological changes on amyotrophic lateral sclerosis patients

Objective To observe the neural electrical pathological changes on amyotrophic la teral sclerosis(ALS)and to evaluate their clinical significance primarily.Methods Routin acu-electromyogram(EMG),nerve conduction velocity,repeated frequency stimulation test were carried on 36ALS patients and th e results were analysed.Results The EMG of ALS manifestated extensiv e injuries derived nerves,such as prolonged duration,high amplitu de,fribrillation potential,and huge potential etc.Small portion of patients had slow sensory or motor nerv e conduction velocity.Part patients had abnormal results of repeated fre quency stimulation test.Conclusion Neural electrical pathological ex-aminations are important assisted measures to ALS and are benefit to understand the pathological mechanism o f ALS.