High-altitude ancestry protects against hypoxia-associated reductions in fetal growth |
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| Authors: | Julian Colleen Glyde Vargas Enrique Armaza J Fernando Wilson Megan J Niermeyer Susan Moore Lorna G |
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| Institution: | Colleen Glyde Julian, University of Colorado Altitude Research Center, University of Colorado at Denver and Health Sciences Center, Campus Box B123, 4200 East Ninth Avenue, Suite 301 (BRB), Denver, Colorado 80262, USA. cgjulian@ouray.cudenver.edu |
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| Abstract: | OBJECTIVE: The chronic hypoxia of high-altitude (>/=2500 m) residence has been shown to decrease birth weight in all populations studied to date. However, multigenerational high-altitude populations appear protected relative to newcomer groups. This study aimed to determine whether such protection exists independently of other factors known to influence fetal growth and whether admixed populations (ie, people having both high- and low-altitude ancestry) show an intermediate level of protection. DESIGN: 3551 medical records from consecutive deliveries to Andean, European or Mestizo (ie, admixed) women at low, intermediate or high altitudes in Bolivia were evaluated for maternal characteristics influencing fetal growth as measured by birth weight and the frequency of small for gestational age births (SGA or
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| Keywords: | genetic adaptation hypoxia intrauterine growth restriction preeclampsia uteroplacental blood flow |
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