| 仙人掌对辐射小鼠bcl-2和p53基因表达影响 |
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| 引用本文： | 梁亦龙,舒坤贤,何伟,韦平,查毅,张燕红,韦衍颜,胡娟. 仙人掌对辐射小鼠bcl-2和p53基因表达影响[J]. 时珍国医国药, 2007, 18(12): 2948-2949 |
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| 作者姓名： | 梁亦龙 舒坤贤 何伟 韦平 查毅 张燕红 韦衍颜 胡娟 |
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| 作者单位： | 重庆邮电大学生物信息学院,重庆,400065 |
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| 基金项目： | 重庆市自然科学基金资助（No.CSTC,2006BB5368） |
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| 摘 要： | 目的测定仙人掌对辐射小鼠bcl-2与p53基因表达影响。方法以UVB辐照制备损伤模型,预先给予仙人掌,以RT-PCR测定仙人掌对辐射小鼠bcl-2与p53基因表达量的影响。结果仙人掌对辐射小鼠bcl-2的基因表达降低有保护作用,使辐射后p53基因表达降低。结论仙人掌具有一定的防辐射作用。其抗辐射作用与其调控细胞bc1-2与p53基因有关。
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| 关 键 词： | 仙人掌 辐射 bcl-2基因 p53基因 |
| 文章编号： | 1008-0805（2007）12-2948-02 |
| 收稿时间： | 2007-03-30 |
| 修稿时间： | 2007-06-12 |
Effects of Opuntia dillenlli on bcl -2 and p53 Gene Expression in Irradiated Mice |
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| LIANG Yi-long,SHU Kun-xian,HE Wei,WEI Ping,ZHA Yi,ZHANG Yan-hong,WEI Yan-yan,HU Juan. Effects of Opuntia dillenlli on bcl -2 and p53 Gene Expression in Irradiated Mice[J]. Lishizhen Medicine and Materia Medica Research, 2007, 18(12): 2948-2949 |
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| Authors: | LIANG Yi-long SHU Kun-xian HE Wei WEI Ping ZHA Yi ZHANG Yan-hong WEI Yan-yan HU Juan |
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| Abstract: | Objective To study the effects of genistein on bone marrow cell cycle,proliferation and expression of bcl-2 gene and p53 gene of normal and irradiated mice.Methods The irradiation damage model of the mice caused by UVB was established.The bcl-2 and p53 mRNA gene expression was also determined with the technology of RT-PCR.Results Opuntia could increase the bc1-2 gene expression and decrease the p53 gene expression in irradiated mice.Conclusion The radioprotective effect of Opuntia is related to regulation of cell apoptosis and bc1-2 and p53 gene expression. |
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| Keywords: | Opuntia dillenii Irradiate bcl-2 gene p53 gene |
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