血清IL-6水平与2型糖尿病患者骨质疏松关系的探讨

目的 探讨血清白介素-6（IL-6）水平与2型糖尿病（T2DM）患者骨质疏松的关系。方法 测定74例T2DM患者及46例年龄、体重指数（BMI）相匹配的健康对照者的血清IL-6水平、骨密度（BMD）、血清骨钙素（BGP）、抗酒石酸磷酸酶（TRAP）、尿羟脯氨酸CHOP），两组进行比较。结果 血清BGP、BMD水平T2DM患者明显低于对照组（P〈0.01，P〈0.05）；TRAP、尿HOP、血清IL-6水平显著高于对照组（P〈0.05），IL-6与BMD呈显著负相关。结论 T2DM患者骨密度降低，其原因与IL-6水平升高有一定关系。

Reationship between levels of IL-6 in serum of patients with type 2 diabetes melhtus and osteoporosis

Objective:To study the role of interleukin-6(IL-6) in onset of osteoporosis in patient with type 2 diabetes mellitus(T2DM). Methods:Dual energy X-ray absorptionmetry was given to determine the bone mineral density (BMD) in 74 patients with T2DM and 46 healthy controls. Serum osteocalcin, tartrate-resistant acid phosphatase(TRAP) , hydroxyprolin(HOP) and IL-6 were measured,and were compared with 46 cases of age and body mass index (BMI)matched controls. Results: The BMD in patients with T2DM markedly decreased and serum osteocalcin was significantly lower than that of controls(P <0. 01), serum TRAP,urinary HOP,IL-6 were significantly higher than those of controls. The changes of BMD were markedly negative correlated with IL-6. Conclusions:There is a higher morbidity osteocalcin in patients with T2DM,the increased expression of IL-6 promotes the bone absorption,which leads to the decrease of bone density.