Melphalan in ultralow doses decreases the severity of experimental colitis in mice |
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| Authors: | A L Pukhalskii G V Shmarina V A Aleshkin |
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| Institution: | (1) Medical and Genetic Research Center, Russian Academy of Medical Sciences, Moscow;(2) G. N. Gabrichevskii Institute of Epidemiology and Microbiology, Russia |
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| Abstract: | We studied the effect of melphalan in ultralow doses on mice with experimental colitis induced by substitution of drinking
water for 5% dextran sulfate. Daily treatment with melphalan in a dose of 0.025 mg/kg improved the general state of animals.
The influence of melphalan was evaluated by quantitative clinical, pathomorphological, and laboratory parameters. Melphalan
had a local and systemic antiinflammatory effect.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 10, pp. 418–422, October, 2006 |
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| Keywords: | alkylating agents melphalan experimental colitis |
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