产后甲状腺炎研究进展

产后甲状腺炎是发生在产后的一种自身免疫性甲状腺疾病。近年来研究表明 ,产后甲状腺炎的发生与细胞免疫、体液免疫和免疫遗传缺陷等均有关。TPOAb、TgAb和可溶性CD4是目前预测产后甲状腺炎发生的较好指标。L T4的应用并不能阻止TPOAb阳性妊娠妇女产后甲状腺炎的发生 ,但可用于该病患者的永久性替代治疗。产后甲状腺炎预后良好 ,但容易复发 ,对易患妇女进行长期随访十分必要。该文对近年来产后甲状腺炎发病机理、发病率、临床实验室特征、防治及预后等方面的研究进展进行了简要综述。

Progress in Study on Post-partum Thyroiditis

Post-partum thyroiditis(PPT) is an autoimmune thyroid disease occurring after parturition. Recent studies indicate that cellular immunity, humoral immunity and immunogenetic deficiency contribute to the onset of PPT. TPOAb, TgAb and soluble CD4 are good predictive indexes for PPT at present. The application of L-T4 will not prevent PPT in pregnant women with TPOAb positive. But it can be used as permanent substitution treatment for the patients. Although the prognostic of PPT is usually favourable, it relapses frequently. A Long-term follow-up of PPT women seems necessary. This review summarizes current progress in pathogenesis, morbidity, clinical and laboratory features, prevention, treatment and prognostic of post-partum thyroiditis briefly.