重症抑郁与痛觉阈值的相关性研究

比较３０例重症抑郁病人与正常对照组的躯体感觉阈（ＳＰＴ）、痛觉阈（ＰＰＴ）及相对痛觉阈（ＲＰＰＴ），并评定汉密尔顿郁量表（ＨＡＭＰ），观察抑郁程度与痛觉阈值改变的相关性。发现重症抑郁病人ＳＰＴ和ＰＰＴ明显高于正常对照组；ＳＰＴ、ＰＰＴ、ＲＰＰＴ值与ＨＡＭＤ总分和各因子分之间无明显相关；重症抑郁发作期与缓解期的ＳＰＴ、ＰＰＴ和ＲＰＰＴ值的自身对比无显著差异。推测绝对知觉阈的增高可能与抑郁症患者体内鸦片样物质系统的功能改变有关。提示内源性疼痛调节系统与抑郁症病理基础既有内在联系，又有相对的独立性，故疼痛可作为抑郁的躯体症状，也可继发或加重抑郁。

Correlative study between major depression and pain perception threshold.

Somatosensory perception threshold (SPT),pain perception threshold (PPT)and the relative pain perception threshold (RPPT) were studied in 30 patients with major depression,compared with the findings in a control group and related to the psychopathological state evaluated by means of the Hamilton Depression Scale (HAMD).We found that SPT,PPT were increased in the patients:SPT,PPT,RPPT, and HAMD or HAMD subscores were not significantly correlated with each other; SPT, PPT, RPPT were nonsignificantly decreased in the recovery from major deperssion.The data suggested that the increase of absolute perception thresholds in depressive patients maybe correlated with the change of the endogenous opiate pain-modulating system.