血清25-羟基维生素D检测在儿童社区获得性肺炎中的应用及意义

目的探讨儿童社区获得性肺炎(CAP)患儿血清25-羟基维生素D水平及临床意义。方法采用电化学发光法和免疫透射比浊法分别测定66例CAP患儿和52名健康体检者(正常对照组)血清25-羟基维生素D和C反应蛋白(CRP)水平,并根据儿童CAP病情的轻重分为轻症组和重症组。结果儿童CAP组血清25-羟基维生素D水平(27.05±10.93)μg/L]明显低于正常对照组(32.77±9.78)μg/L](P0.01),而CRP水平(11.77±5.98)mg/L]则高于正常对照组(4.56±2.48)mg/L](P0.01)。同时,重症组血清25-羟基维生素D水平明显低于轻症组(P0.01),而平均年龄则大于轻症组(P0.01);CRP水平在两组之间无明显差异(P0.05)。结论血清25-羟基维生素D的缺乏可能是儿童CAP的潜在病因,在判断疾病的轻重上也有一定的意义。

The application and significance of serum 25-hydroxyvitamin D determination in children with communityacquired pneumonia

Objective To investigate serum 25-hydroxyvitamin D level and its clinical significance in communityacquired pneumonia（ CAP） children. Methods The level of serum 25-hydroxyvitamin D and C-reactive protein（ CRP） were determined in 66 children with CAP and 52 healthy subjects（ healthy control group） by electrochemiluminescence immunoassay and turbidimetry immunoassay. The children were classified into mild symptom group and intensive symptom group according to the severity of CAP. Results The level of serum 25-hydroxyvitamin D in CAP group（ 27. 05 ± 10. 93） μg /L]was obviously lower than that in healthy control group（ 32. 77 ± 9. 78） μg /L]（ P 0.01）. However,CRP in CAP group （ 11. 77 ±5. 98） mg/L]was higher than that in healthy control group（ 4.56 ±2.48） mg/L]（ P 0.01）. Meanwhile,the level of serum 25-hydroxyvitamin D in intensive symptom group was lower than that in mild symptom group,and the average age in intensive symptom group was elder than that in mild symptom group（ P 0. 01）,but there was no statistical significance for CRP between the 2 groups（ P 0. 05）.Conclusions The lack of serum 25-hydroxyvitamin D may be the potential role for CAP in children,and there also is a certain significance in judging the severity of disease.