心理行为干预对门诊首发精神分裂症患者的影响

目的探讨心理行为干预对门诊首发精神分裂症患者的影响。方法选择2011年6月-2012年6月在我院门诊首次发病并治疗的精神分裂症患者90例，随机分为对照组和研究组各45例。对照组采用精神科常规治疗和常规告知注意事项，研究组在此基础上配合心理行为干预，进行为期6个月的治疗与观察。在治疗前及治疗第1、2、3、6月末分别用阳性与阴性症状量表（PANSS）及治疗中出现的症状量表（TESS）进行疗效评定和不良反应。用世界卫生组织编制的生活质量量表（WHOQOL-100）评定生活质量。结果对照组及研究组第1、2、3、6月末，PANSS总分及各因子分均显著下降（P〈0．05或0．01），且同期两组间PANSS评分比较差异有统计学意义（P〈0．05或〈0．01）。同期两组间TESS差异无统计学意义。治疗6月末，两组WHOQOL-100各领域评分较治疗前均明显改善（P〈0．05或〈0．01），且研究组与对照组的差异有统计学意义（P均〈0．01）。结论心理行为干预能提高门诊精神分裂症患者的疗效和生活质量。

The Influence of Psychological Behaviour Intervention in Outpatients with First-episode Schizophrenia

Objective To discuss the influence of psychological behaviour intervention in outpatients with schizophrenia. Methods A total of 90 outpatient with first-episode schizophrenia in our hospital from 2011,6 to2012,6 ,were randomly dividided into control group （45 cases）and study group（45 cases）. The patients in control group were treated with psychiatric routine therapy and nursing care. And patients in study group added psychological behaviour intervention. The course of treatment and observation was 6 months. The efficacy and side effects were evaluated by the Positive and Negatice Syndrome Scale（PANSS） and adverse reactions with the Treatment Emergent Symptom Scale （TESS）before and after treatment for 1,213,6 months. The quality of life was measured by World Health Organization quality of life questionnaire（ WHOQOL - 1013）. Results The total score of PANSS obviously decreased in both groups at the treatment of 1,2,3,6 month （P 〈 0.01 ）. And there was significant difference between the two groups of PANSS （P 〈 0.05 ）. There was no significant difference between the two groups of TESS（ P 〉 0.05 ）. And there was significant difference between the two groups of WHOQOL - 100 ut the treatment of 6 month（ P 〈 0.05 or 〈 0.01 ）. Conclusion Psychological behaviour intervention can improve the efficacy and quality of life of outpatients with first-episode schizophrenia.