难治性与一般性抑郁症患者冲突性负波的对比研究

目的 探讨难治性与一般抑郁症患者事件相关电位N270指标的变化差异.方法 对20例难治性抑郁症患者（难治组）、26例一般性抑郁症患者（非难治组）进行事件相关电位N270检查,与22名健康志愿者的结果进行比较.结果 与对照组相比,P3、P4、Cz3个电极上,难治组N270潜伏期显著延迟（t=4.24,4.65,5.12;P＜0.05）,波幅显著降低（t=3.63,3.82,4.17;P＜0.05）；非难治组N270潜伏期差异不显著,波幅显著降低（t=2.56,2.62,3.02;P ＜0.05）.与非难治组相比,难治组N270潜伏期显著延迟（=3.62,3.22,4.12；P＜0.05）,波幅降低值显著偏大（t=2.26,2.45,2.83；P＜0.05）.结论 抑郁症患者的冲突信息加工功能受损,难治性抑郁患者受损程度大于一般性抑郁症患者.提示N270变化指标可能是难治性抑郁患者的潜在生物学标记.

Comparative Study on Conflict Negative Wave between Treatment-resistant Depression and General Depression

Objective To explore the difference of event-related potential N270 between treatment-resistant depression and general depression. Methods A total of 20 cases of treatment-resistant depressions （ TRD group） and 26 cases of general depressions （ NTRD group） hospitalized in Third Hospital of PLA from April 2012 to December 2012 were selected, event-related potentials N270 was tested and compared with 22 cases of healthy subjects （ control group）. Results Compared with the control group, at the P3, P4, Cz three electrodes, treatment-resistant depressions group had significantly longer latency periods of N270 （ t = 4. 24,4. 65,5.12 ;P 〈 0.05 ） and lower amplitudes of N270 （ t = 3.63,3.82,4. 17 ; P 〈 0.05 ） ; No statistical difference of latency periods of N270 was found and the amplitudes of N270 were longer in the general depressions group （t = 2. 56,2. 62,3.02;P 〈 0. 05 ）. Compared with the general depressions group, the treatment-resistant depressions group had significantly longer latency periods of N270 （ t = 3.62,3.22,4. 12 ; P 〈 0.05 ） and significantly larger amplitude reduced value （ t = 2. 26,2. 45,2. 83 ;P 〈 0. 05 ）. Conclusion Depression patients are impaired on conflict information processing function, and the extent of damage in the treatment-resistant depressions is larger than general depressions. It is suggested that N270 change indicators may be the potential biomarker on treatment-resistant depressions.