| Effect of Plasmodium yoelii YM Infection on Vaccination with 19 kDa Carboxylterminus of the Merozoite Surface Protein 1 （MSP1 19） |
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| 引用本文： | 徐沪济,JiraprapaWIPASA,刘雪琴,AnthonySTOWERS,杨晓平,MichaelFGOOD. Effect of Plasmodium yoelii YM Infection on Vaccination with 19 kDa Carboxylterminus of the Merozoite Surface Protein 1 （MSP1 19）[J]. 中华微生物学和免疫学杂志(英文版), 2004, 2(4): 265-271 |
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| 作者姓名： | 徐沪济 JiraprapaWIPASA 刘雪琴 AnthonySTOWERS 杨晓平 MichaelFGOOD |
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| 作者单位： | Department of Rheumatology and Immunology，Changzheng Hospital，Second Military Medical University，Shanghai 200003，China Division of Infection and Immunity，Institute of Immunology，Second Military Medical University，200043，China The Cooperative Research Center for Vaccine Technology，The Queens- land Institute of Medical Research，P.O. Royal Brisbane Hospital，Queens- land 4029，Australia，The Cooperative Research Center for Vaccine Technology，The Queens- land Institute of Medical Research，P.O. Royal Brisbane Hospital，Queens- land 4029，Australia，The Cooperative Research Center for Vaccine Technology，The Queens- land Institute of Medical Research，P.O. Royal Brisbane Hospital，Queens- land 4029，Australia，The Laboratory of Parasitic Diseases，National Institute of Allergy and Infectious Diseases，The National Institutes of Health，Bethesda，MD 20892，USA，Department of Rheumatology and Immunology，Changzheng Hospital，Second Military Medical University，Shanghai 200003，China Division of Infection and Immunity，Institute of Immunology，Second Military Medical University，200043，China，The Laboratory of Parasitic Diseases，National Institute of Allergy and Infectious Diseases，The National Institutes of Health，Bethesda，MD 20892，USA |
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| 摘 要： | The 19 kDa carboxylterminal fragment of merozoite surfaceprotein 1 (MSP119) is a leading malaria vaccine candidate[1]. Immunization of monkeys [ 2 , 3 ] or mice [ 4 , 5 ]with recombinant MSP119 confers protection against chal-lenge infection. Studies in m…
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| 关 键 词： | 疟疾 寄生虫感染 特异性免疫反应 CD4 T细胞 疫苗接种 裂殖子表面蛋白1 |
Effect of Plasmodium yoelii YM Infection on Vaccination with 19 kDa Carboxylterminus of the Merozoite Surface Protein 1 (MSP1_(19) ) |
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| Affiliation: | [2]DepartmentofRheumatologyandImmunology,ChangzhengHospital,SecondMilitaryMedicalUniversity,Shanghai200003,China [3]TheCooperativeResearchCenterforVaccineTechnology,TheQueenslandInstituteofMedicalResearch,P.O.RoyalBrisbaneHospital,Queensland4029,Australia [4]TheLaboratoryofParasiticDiseases,NationalInstituteofAllergyandInfectiousDiseases,TheNationalInstitutesofHealth,Bethesda,MD20892,USA |
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| Abstract: | We have previously demonstrated the ability of malaria parasites to interfere with specific immune responses. CD4 T cells specific to parasite antigens, but not CD4 T cells specific to an irrelevant antigen, ovalbumin (OVA), are de- leted via apoptosis during malaria infection. It is of interest, therefore, to investigate the immune responses that developed following vaccination with the 19 kDa carboxylterminus of the merozoite surface protein 1 (MSP119) in mice that had previ- ously experienced malaria infection. In this study, pre-exposure of mice to Plasmodium yoelii elicited native anti-MSP119 an- tibody responses, which could be boosted by vaccination with recombinant MSP119 . likewise, infection of MSP119-primed mice with Plasmodium yoelii ( P . yoelii) led to an increase of anti-MSP119 antibodies. MSP119 vaccination of malaria pre- exposed mice or immunization by infection/cure of MSP119-primed mice enabled the mice to survive challenge infection, with the former group having slightly lower parasitaemia. The data suggest that exposure to malaria infection primes a natural im- mune response which can be boosted by vaccination. This information is relevant to the development of a vaccine for use in individuals living in malaria-endemic areas. |
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| Keywords: | Antibodies Parasitic-Protozoan Vaccination |
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