大承气汤抗急性坏死性胰腺炎肺损伤的实验研究

为研究急性坏死性胰腺炎（ＡＮＰ）早期白细胞粘附强弱和肿瘤坏死因子（ＴＮＦ）的变化及其与肺损伤的关系，以及大承气能否减轻肺损伤的程度，将１４只家犬随机分成承气汤组（ｎ＝５，ＡＮＰ模型＋大承气汤治疗），盐水组（ｎ＝５，ＡＮＰ模型＋生理盐水治疗）和假手术组（ｎ＝４）３组。术后在流室系统下观察白细胞与内皮细胞的粘附强弱，并测定血清及支气管肺泡灌洗液（ＢＡＬＦ）ＴＮＦ活性和损伤程度。结果显示：实验犬ＡＮＰ时

Experimental study of ta chengchi tang decoction for relieving lung injury during acute necrotizing pancreatitis]

The objectives of the study were to investigate the changes of leukocyte adhesiveness and tumor necrosis factor (TNF) in the early stage of acute necrotizing pancreatitis (ANP), to go further into the relation of those changes to lung injury of ANP, and to evaluate the prohibitive effect of ta chengchi tang Decoction on leukocyte adhesion and TNF secretion. 14 canines were randomly divided into 3 groups. The treatment group (n = 5): experimental ANP model treated with ta chengchi tang Decoction; the saline control group (n = 5): experimental ANP model treated with normal saline; and the sham operative group (n = 4). The adhesion of leukocytes to vascular endothelial cells and TNF activities in serum and in bronchi-alveolar lavage fluid (BALF) were observed and measured, and the degrees of lung injury were assessed. The results showed that the adhesiveness of leukocytes was markedly increased and the activities of TNF were elevated in peripheral blood and BALF during ANP; that the leukocyte adhesiveness in the treatment group was weaker than that in the saline group (P < 0.05) and the serum and BALF TNF activities were also significantly lower than those in the saline group (P < 0.01); and that the degrees of lung injury in the treatment group were significantly milder than those in the saline group. These indicate that the increased leukocyte adhesiveness and hypersecretion of TNF take part in the pathogenesis of lung injury in ANP, and ta chengchi tang Decoction is demonstrated an efficacious medicine for alleviating the degree of lung injury mediated by both the leukocyte adhesion and TNF in ANP.