普拉西坦在动物体内的药物代谢动力学

为研究普拉西坦在犬和大鼠体内药代动力学规律，给犬灌服普拉西坦后，抽取不同时间的血液，分离血浆，用ＨＰＬＣ测定血浆中药物浓度，采用３ｐ８７程序计算药代参数；应用ＨＰＬＣ测定大鼠灌服普拉西坦后各组织和胆汁、尿、粪中药物浓度。结果显示：血药浓度－时间曲线符合一室开放模型，其体内的Ｔ１／２为２．３～３．９小时；大鼠灌服普拉西坦后３小时各组织中有较高的浓度，以肾脏为同，肝脏次之，依序为肠、肺、肌、心、生殖腺

Pharmacokinetics of pramiracetam in animals]

Pharmacokinetic rules of pramiracetam were studied here. After giving pramiracetam orally to dogs, we drew their blood at various times. The drug concentrations in blood plasma were detected by HPLC. 3p87 program was used to calculate the pharmacokinetic parameters. The time-concentration curve corresponded to one apartment model. T1/2 was about 2.3-3.9 hours in various doses. After pramiracetam was given to rats per os, high concentrations of pramiracetam were detected in the rats' tissues. The kidney had the highest concentration of pramiracetam; the liver had the next highest concentration, and then the intestine, lung, muscle, heart, gonad, spleen and sebum had the high concentration in order. The drug was also detected in the brain. 0.7% of the given dose was excreted in unchanged form in bile in 24 hours. 28.26% and 6.35% were excreted in urine and feces respectively in 72 hours. The plasma protein combining rate detected by the method of balance dialysis was 20.1-22.2%.