Immunoperoxidase examination of cutaneous infiltrates of mycosis fungoides and large-plaque atrophic parapsoriasis with OKT10 |
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Authors: | E M McMillan S Peters I Jackson R Wasik L Stoneking M A Everett S L Hamzavi |
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Institution: | 1. Departments of Dermatology and Pathology, University of Oklahoma Health Sciences Center, Oklahoma City;2. the Department of Dermatology and Syphilology, University Health Center, Detroit |
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Abstract: | A monoclonal antibody (OKT10), which was developed recently, reacts with pro-thymocytes, T cell acute lymphoblastic leukemia (ALL) cells, cells in normal bone marrow (including plasma cells), and activated T cells. Tissues from patients with cutaneous T cell lymphoma were studied for the presence of OKT10-reactive cells with the use of an indirect immunoperoxidase technic. OKT10-reactive cells were identified in three of eight cases of mycosis fungoides, one of two cases of Sézary syndrome, with an equivocal reaction in one of ten cases of large-plaque parapsoriasis and in one of seven positive patch tests (allergic contact dermatitis). The biologic and possible clinical implications are discussed. |
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Keywords: | Reprint requests to: Euan M McMlillan M R C P (U K ) 619 N E 13th St Oklahoma City OK 73104 |
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