| 尾加压素Ⅱ与血管重构 |
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| 引用本文： | 李军,张勇刚,李玉光. 尾加压素Ⅱ与血管重构[J]. 心脏杂志, 2007, 19(5): 606-610 |
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| 作者姓名： | 李军 张勇刚 李玉光 |
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| 作者单位： | 汕头大学医学院第一附属医院心内科,广东,汕头,515041 |
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| 基金项目： | 国家自然科学基金;中国博士后科学基金 |
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| 摘 要： | 血管重塑与多种临床疾病有密切关系。尾加压素Ⅱ 是迄今为止在哺乳动物体内发现的最强的缩血管活性肽，参与了多种心血管疾病的病理生理过程，新近研究发现它在血管重塑过程中亦发挥着重要作用。
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| 关 键 词： | 尾加压素Ⅱ 血管重构 信号转导 Urotensin Ⅱ |
| 文章编号： | 1009-7236（2007）05-606-05 |
| 收稿时间： | 2006-09-28 |
| 修稿时间： | 2007-01-22 |
Urotensin Ⅱ and vascular remodeling |
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| LI Jun,ZHANG Yong-gang,LI Yu-guang. Urotensin Ⅱ and vascular remodeling[J]. Chinese Heart Journal, 2007, 19(5): 606-610 |
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| Authors: | LI Jun ZHANG Yong-gang LI Yu-guang |
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| Affiliation: | Department of Cardiovascular Diseases, First Affliated Hospital, Shantou University Medical College, Shantou 515041, Guang dong China |
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| Abstract: | Urotensin Ⅱ is one of the most potent vasoconstrictor known, even more potent than endothelin-1. It was first isolated from the fish urophyses and has been recognized as a hormone in the neurosecretory system of teleost fish for over 30years. After the identification of U-Ⅱ in humans and the orphan human G-protein-coupled receptor 14 ( GPR14 ) as U-Ⅱ receptor( UT), many studies have shown that U-Ⅱ may play an important role in cardiovascular regulation. The present review suggess that U-Ⅱ may also bring into full play in vascular remodeling. In the text, we reviewed the physiological and pathophysiological significance of U-Ⅱ in the vasculature, and focused on the correlation between U-Ⅱ and vascular remodeling. |
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| Keywords: | vascular remodeling signal transduction |
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