雄激素性秃发的遗传机制研究现状

雄激素性秃发是脱发中最常见的类型,其发病机制尚不完全清楚.认为它是一种雄激素依赖性的、具有遗传特性的多基因遗传病.第一个发现的雄激素性秃发易感基闪一雄激素受体基因,位于X染色体上;另外,位于Y染色体上的性别决定基因、常染色体上的脱发基因等也与雄激素性秃发发病有关.最近,有学者通过对全基因扫描分析和精确定位,发现了雄激素性秃发新的易感位点-3q26和20p11,为研究雄激素性秃发的遗传机制提供了新的线索.

Genetic mechanism of androgenic alopecia

Androgenic alopecia(AGA) is the most common type of hair loss.Its pathogenesis remains unclear.Now AGA is defined as an androgen-dependent disease with characteristic multifactorial inheritance.Androgen receptor gene located on the X chromosome was first found as a susceptibility gene of AGA.Further more,the sex-determining gene located on the Y chromosome and the hairless gene on the autosome gene were also associated with AGA.Recently,scholars have revealed another two susceptibility loci on chromosome 3 q 26 and 20 p11 using genome-wide scan and fine-mapping linkage methods,which may provide further clues to the research of genetic mechanism of AGA.