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| 结直肠癌患者IL-6基因启动子-174G→C多态性研究 | |
| 引用本文： | 陈江辉,李登清,陈子华.结直肠癌患者IL-6基因启动子-174G→C多态性研究[J].中国普通外科杂志,2007,16(4):12-340. |
| 作者姓名： | 陈江辉 李登清 陈子华 |
| 作者单位： | 1. 中南大学湘雅医院麻醉科,湖南,长沙,410008 2. 中南大学湘雅医学院检验系,湖南,长沙,410013 3. 中南大学湘雅医院胃肠科,湖南,长沙,410008 |
| 摘 要： | 目的：观察结直肠癌患者是否存在IL-6基因启动子-174G→C位点的多态性。方法：采用PCR扩增、限制性内切酶片段长度多态性（RFLP）分析判断46例结直肠患者IL-6启动子-174G→C多态性。结果：全组结直肠癌患者IL-6基因启动子-174位点均为GG型。结论：本组结直肠癌患者中未发现IL-6基因启动子-174位点的多态性。 |
| 关 键 词： | 结直肠肿瘤 白细胞介素6 基因多态性 基因 结构 |
| 文章编号： | 1005-6947（2007）04-0338-03 |
| 收稿时间： | 2006-11-28 |
| 修稿时间： | 2007-03-28 |
Investigation of -174G→C polymorphism of the IL-6 gene promoter in patients with colorectal cancer |
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| CHEN Jiang-hui,LI Deng-qing,CHEN Zi-hua.Investigation of -174G→C polymorphism of the IL-6 gene promoter in patients with colorectal cancer[J].Chinese Journal of General Surgery,2007,16(4):12-340. | |
| Authors: | CHEN Jiang-hui LI Deng-qing CHEN Zi-hua |
| Institution: | 1 , Department of Anesthesia 3 General Surgery , Xiangya Hospital, Central South University , Changsha 410008 , China. 2, Department of Medical Laboratory , Xiangya Medical College, Central South University , Changsha 410013, China |
| Abstract: | Abstract:Objective：To detect -174G→C polymorphism of IL-6 gene promoter in patients with colorectal cancer. Methods ：-174G→C polymorphism of IL-6 gene promoter was detected by PCR-RFLP in 49 patients with colorectal cancer.Results：-174G→C polymorphism of IL-6 gene promoter in all the 46 patients with colorectal cancer was -174G/G genotype.Conclusions：-174G→C polymorphism of IL-6 gene promoter was not found in 49 patients with colorectal cancer. |
| Keywords: | Colorectal Neoplasms Interleukin-6 Gene Polymorphism Gene Structural |
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