Reduction of plasma and urinary vasopressin during treatment of severe hypertension by captopril |
| |
Authors: | M. THIBONNIER M. E. SOTO J. MENARD J. C. ALDIGER P. CORVOL P. MILLIEZ |
| |
Affiliation: | Service du Professeur Milliez, Hôpital Broussais, 96 rue Didot, 75014 Paris;*INSERM U 36, 17 rue du Fer àMoulin, 75005 Paris, France |
| |
Abstract: | Abstract. Plasma concentrations and urinary excretion rate of vasopressin (VP) were examined in ten cases of severe hypertension before and during short-term treatment by Captopril (SQ 14 225). Before Captopril, plasma and urinary VP were high (respectively 5.24 pmol/1 and 68 pmol/day) and positively correlated to plasma renin activity (PRA) and plasma aldosterone (PA). The decline in blood pressure (mean —15%) after Captopril was correlated not only to initial PRA and PA values, but also to plasma ( r = 0.89; P < 0.001) and urinary ( r = 0.78; P < 0.01) VP values. The initial dose of Captopril (1 mg/kg) induced a rapid decrease in blood pressure whereas plasma VP did not rise and aldosterone decreased. At the eighth day of Captopril treatment (mean daily dose 6±1.5 mg/kg) the drop in blood pressure (— 12%) and in aldosterone persisted together with a significant reduction in plasma (1.18 pmol/1; P <0.01) and urinary (25 pmol/day; P <0.01) VP. It is suggested that these sustained simultaneous reductions in the rates of secretion of vasopressin and aldosterone are both elements of the antihypertensive effect of Captopril. |
| |
Keywords: | Vasopressin Captopril severe hypertension |
|
|