| 氟哌啶醇对兔心脏电生理参数的影响 |
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| 引用本文： | 王水珠,邱汉婴,张小勇,饶志荣. 氟哌啶醇对兔心脏电生理参数的影响[J]. 汕头大学医学院学报, 2003, 16(3): 137-139 |
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| 作者姓名： | 王水珠 邱汉婴 张小勇 饶志荣 |
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| 作者单位： | 1. 江西省新余市人民医院心血管内科,江西,新余,338025
2. 汕头大学医学院第二附属医院心血管内科,广东,汕头,515041 |
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| 摘 要： | 目的 :研究氟哌啶醇 (Hal)对兔心脏电生理参数的影响。方法 :使用心房起搏电极和心室壁插入电极 ,观察Hal(1 0mg kg或 2 0mg kg ,iv .)对兔心脏电生理参数的影响。结果 :用药后 10、 30、 6 0min ,心房舒张期阈值、心室舒张期阈值显著提高 (P <0 0 5 ,P <0 0 1) ;呈剂量依赖关系 ,平均动脉压显著下降 (P <0 0 1) ;心率显著减慢 ,心房相对不应期、心房有效不应期、心室相对不应期、心室有效不应期显著延长 (P <0 0 5 ,P <0 0 1)。结论 :Hal具有减慢心率 ,延长兔心房、心室不应期的作用
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| 关 键 词： | 氟哌啶醇 兔 心脏 电生理参数 Hal 精神病 |
| 文章编号： | 1007-4716(2003)03-0137-03 |
| 修稿时间： | 2003-05-29 |
Effect of Haloperidol on Electrophysiological Parameters in the Rabbit Heart |
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| WANG Shui-zhu. Effect of Haloperidol on Electrophysiological Parameters in the Rabbit Heart[J]. Journal of Shantou University Medical College, 2003, 16(3): 137-139 |
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| Authors: | WANG Shui-zhu |
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| Abstract: | Objective:To study the effect of haloperidol(Hal)on electrophysiological parameters in the rabbit heart.Method:The atrial pacing electrode and ventricular plunge electrode were used to observe the effect of Hal(1.0mg/kg or 2.0mg/kg,iv.)on electrophysiological parameters in the rabbit heart.Results:The atrial diastolic threshold(ADT)and the ventricular diastolic threshold(VDT) were significantly increased(P<0.05,P<0.01),10,30,and 60 minutes after injected with Hal.The mean arterial blood pressure(MABP) and the HR significantly were decreased (P<0.05,P<0.01).The atrial relative refractory perild(ARRP),the atrial effective refractory period(AERP),the ventricular relative refractory period(VRRP)and the ventricular effective refractory period(VERP)were significantly prolonged(P<0.05,P<0.01).Conclusion:Hal may have the effect of prolongating atrial and ventricular refractory period. |
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| Keywords: | Haloperidol Rabbit Electrophysiology |
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