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Urinary acidification in extremely low birth weight infants |
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| Authors: | Sato Takashi Takahashi Naoto Komatsu Yasuhiro Wada Masaki Matsunaga Masamichi Ito Katsumi Uchiyama Makoto Nishida Hiroshi |
| Affiliation: | a Department of Pediatrics, Niigata University, 1-757, Asahimachi, Niigata, Niigata, 951-8510, Japan b Maternal and Perinatal Center, Tokyo Women's Medical University, Tokyo, Japan c Department of Internal Medicine, St. Luke's International Hospital, Japan d Department of Pediatric Nephrology, Tokyo Women's Medical University, Kidney Center, Japan |
| Abstract: | Premature infants often present metabolic acidosis without protein load in the early neonatal period, around days 4–6. In order to elucidate the cause of acidosis, we investigated urinary acidification of infants in the early neonatal period. Urine pH, fractional excretion of HCO3− (FEHCO3), excretion of HCO3− and NH4+ of the appropriate-for-date infants were measured on days 0–2 and on days 4–6 of life. Extremely low birth weight (ELBW) infants showed higher urine pH than more than 1500 g birth weight infants. FEHCO3 and HCO3− excretion were of high values in ELBW infants on days 0–2, but decreased on days 4–6. Urine NH4+ excretion rate was lower in ELBW infants than in birth weight more than 1000 g on days 0–2 of life and still remained at a low rate on days 4–6. These data indicated that insufficiency of NH4+ excretion is the main cause for metabolic acidosis of ELBW infants in the early neonatal period. |
| Keywords: | Urinary acidification Extremely low birth weight infant Ammonium excretion Bicarbonate reabsorption |
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