| 恩替卡韦治疗HBeAg阳性慢性重度乙型肝炎临床疗效 |
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| 引用本文： | 颜海弟,郑石洲. 恩替卡韦治疗HBeAg阳性慢性重度乙型肝炎临床疗效[J]. 国际医药卫生导报, 2010, 16(2): 196-199. DOI: 10.3760/cma.j.issn.1007-1245.2010.02.024 |
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| 作者姓名： | 颜海弟 郑石洲 |
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| 作者单位： | 湛江市第二人民医院,524003;湛江市第二人民医院,524003 |
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| 摘 要： | 目的评估恩替卡韦治疗HBeAg阳性慢性重度乙型肝炎临床疗效。方法将HBeAg阳性慢性重度乙型肝炎患者58例随机分为治疗组29例和对照组29例,治疗组用恩替卡韦0.5 mg/天治疗,疗程为48周,前4周加用保肝药物治疗。对照组患者保肝治疗,疗程为48周。结果治疗组ALT复常率（93.1%）、HBeAg阴转率（44.8%）、HBeAg/抗HBe转换率（41.4%）、HBV DNA阴转率93.1%均显著高于对照组（P值〈0.05）,且治疗组肝组织病理炎症活动度好转率（93.1%）和纤维化好转率（72.4%）也显著高于对照组（P值〈0.05）,对照组有13.8%发生重型肝炎和13.8%发生肝硬化,而治疗组无病人发生重型肝炎和肝硬化（P值〈0.05）。结论恩替卡韦对HBeAg阳性慢性重度乙型肝炎有较好的临床疗效,能阻止重型肝炎和肝硬化的发生。
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| 关 键 词： | 恩替卡韦 HBeAg阳性 慢性乙型肝炎 重度 |
Efficacy of Entecavir for patients of chronic severe-degree hepatitis B with HBeAg-posi-tive |
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| YAN Hai-di,ZHENG Shi-zhou. Efficacy of Entecavir for patients of chronic severe-degree hepatitis B with HBeAg-posi-tive[J]. International Medicine & Health Guidance News, 2010, 16(2): 196-199. DOI: 10.3760/cma.j.issn.1007-1245.2010.02.024 |
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| Authors: | YAN Hai-di ZHENG Shi-zhou |
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| Affiliation: | .( The seeond people＇s hospital of Zhanjiang, Zhanjiang 524003, China) |
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| Abstract: | Objective To evaluate the effects of Entecavir for patients of chronic severe-degree hepatitis B with HBeAg-positive.Methods 58 patients with chronic severe-degree hepatitis B were randomly divided into two groups(treatment group and control group).29 patients in the treatment group were treated with Entecavir 0.5mg/d for 48 weeks and protect-liver drug for the first 4 weeks.29 patients in control group were treated with protect-liver drug for 48 weeks.Results After therapy for 48 weeks,ALT normalization-ra... |
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| Keywords: | Entecavir HBeAg-positive Chronic hepatitis B Severe-degree |
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