靶向DNA损伤应答关键分子在肿瘤放疗增敏中的应用

放射治疗是临床肿瘤治疗的重要手段,主要通过破坏DNA双链对肿瘤细胞造成严重损伤。然而,其作为单一的治疗手段,治疗效果受肿瘤细胞固有DNA损伤修复能力的影响。多项研究表明,靶向调节DNA损伤响应关键分子可以有效抑制DNA损伤修复,协同增强放化疗敏感性。本文对一些关键的DNA损伤响应抑制剂联合放疗、化疗在多种肿瘤治疗中的应用进行了总结,并阐述了联合治疗诱导由环鸟嘌呤核苷酸腺嘌呤核苷酸合成酶-干扰素基因刺激因子介导的免疫反应。最后总结和展望了联合治疗存在的挑战和发展前景。

Applications of key molecules targeting DNA damage response in tumor radiosensitization

Radiotherapy, an important method for clinically treating tumors, causes serious damage to tumor cells primarily by destroying DNA double strands. However, the outcomes of radiotherapy alone are limited by tumor cells'' inherent capacity for DNA damage repair. Multiple studies have shown that key molecules targeting DNA damage response (DDR) can effectively inhibit DNA damage repair while synergistically enhancing radiotherapy and chemotherapy sensitivity. This study reviews the applications of some key DDR inhibitors combined with radiotherapy or chemotherapy in the treatment of various tumors, elaborates on cyclin guanine nucleotide adenine nucleotide synthase-interferon gene stimulator (cGAS-STING)-mediated immune responses induced by combination therapy, and finally summarizes and predicts the challenges and development prospects of combination therapy.