与微管作用的抗肿瘤天然产物的研究进展

自从紫杉醇广泛应用于临床治疗以来,与微管作用的抗肿瘤天然产物的发现、化学修饰和机制研究已经成为学术和临床研究的热点。介绍了与微管作用的抗肿瘤天然产物的研究情况,包括紫杉醇、埃博霉素、disco-dermolid、考布他汀、软海绵素、海兔毒素、那可丁等,简要探讨了目前存在的问题和未来的发展方向。

Anticancer natural products with tublin-interactive properties

After taxol was widely used in clinical treatments, the discovery, chemical modification and mechanism study of anticancer natural products with tublin-interactive properties have become focal point of research both in academic and clinical field. This review provides brief information and recent development of anticancer natural products with tublin-interactive properties such as Paclitaxel, epothilones, discodermolid, combretastatin, halichondrin, dolastatin, noscapine. The disadvantage and future development of anticancer agents are also discussed in this article.