氨溴索对COPD患者血清自细胞介素-17和肺功能的影响

目的探讨氨溴索对COPD患者血清细胞因子白介素-17（IL-17）水平和肺功能的影响。方法选择120例COPD患者随机分为氨溴索组60例和对照组60例，比较两组治疗后血清细胞因子IL-17水平和肺功能的变化。结果氨溴索组治疗前后血清IL—17水平差值显著大于对照组（P〈0．01），肺功能1秒钟用力呼气容积占预计值百分比（FEV1％）、1秒钟用力呼气容积／肺活量（FEV1／FVC）差值显著大于对照组（P〈0．01）。结论氨溴索能显著降低COPD患者血清炎症细胞因子IL-17水平，减轻炎症反应，显著改善通气功能。

The Effect of Ambroxol on Concentrations of Serum IL-17 and Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease

Objctive To investigate the effect of ambroxol on concentrations of serum IL-17 and pulmonary function in patients with chronic obstructive pulmonary disease （COPD）. Methods One hundred and twenty hospitalized patients with COPD in our hospital were divided into the ambroxol group（n=60） and control group（n=60）. Concentrations of serum IL-17 and pulmonary function parameter included the ratio of forced expiratory volume in one second and predicted value （FEV1%） and forced expiratory volume in one second divided by forced vital capacity （FEV1/FVC） were measured. Results The difference value of serum IL-17 concentrations and FEV1%,FEV1/FVC in the ambroxol group were significantly higher than those in the control group （P〈0.01）. Conclusion Ambroxol can reduce the concentrations of serum IL-17,relieve inflammatory reaction and improve ventilation function significantly in patients with COPD.