氨溴索对COPD患者血清自细胞介素-17和肺功能的影响 |
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引用本文: | 高云霄,刘元昆.氨溴索对COPD患者血清自细胞介素-17和肺功能的影响[J].中国现代医生,2011,49(18):231-232. |
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作者姓名: | 高云霄 刘元昆 |
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作者单位: | 浙江省新昌县人民医院呼吸内科; 浙江新昌312500 |
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摘 要: | 目的探讨氨溴索对COPD患者血清细胞因子白介素-17(IL-17)水平和肺功能的影响。方法选择120例COPD患者随机分为氨溴索组60例和对照组60例,比较两组治疗后血清细胞因子IL-17水平和肺功能的变化。结果氨溴索组治疗前后血清IL—17水平差值显著大于对照组(P〈0.01),肺功能1秒钟用力呼气容积占预计值百分比(FEV1%)、1秒钟用力呼气容积/肺活量(FEV1/FVC)差值显著大于对照组(P〈0.01)。结论氨溴索能显著降低COPD患者血清炎症细胞因子IL-17水平,减轻炎症反应,显著改善通气功能。
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关 键 词: | 氨溴索 慢性阻塞性肺疾病(COPD) IL-17 肺功能 |
The Effect of Ambroxol on Concentrations of Serum IL-17 and Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease |
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Authors: | GAO Yunxiao LIU Yuankun |
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Institution: | Respiration Department of People’s Hospital of Xinchang County,Xinchang 312500,China |
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Abstract: | Objctive To investigate the effect of ambroxol on concentrations of serum IL-17 and pulmonary function in patients with chronic obstructive pulmonary disease (COPD). Methods One hundred and twenty hospitalized patients with COPD in our hospital were divided into the ambroxol group(n=60) and control group(n=60). Concentrations of serum IL-17 and pulmonary function parameter included the ratio of forced expiratory volume in one second and predicted value (FEV1%) and forced expiratory volume in one second divided by forced vital capacity (FEV1/FVC) were measured. Results The difference value of serum IL-17 concentrations and FEV1%,FEV1/FVC in the ambroxol group were significantly higher than those in the control group (P〈0.01). Conclusion Ambroxol can reduce the concentrations of serum IL-17,relieve inflammatory reaction and improve ventilation function significantly in patients with COPD. |
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Keywords: | Ambroxol Chronic obstructive pulmonary disease IL- 17 Pulmonary function |
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