通脉方对2型糖尿病早期下肢动脉血管病变患者动脉粥样硬化的影响

目的 观察通脉方对2型糖尿病（T2DM）早期下肢动脉血管病变 (LEAD) 患者动脉粥样硬化（AS）的影响。

Effect of Tongmai Recipe on Atherosclerosis in Patients with Early Lower Extremity Arteriopathy Caused by Type 2 Diabetes Mellitus

Objective To observe the effect of Tongmai Recipe （TMR） on atherosclerosis （AS） in patients with early lower extremity arteriopathy disease （LEAD） caused by type 2 diabetes mellitus （T2DM）. Methods Patients were randomly assigned to two groups. The 23 patients in the treatment group were treated by TMR and the 22 in the control group were given Cilostazo, all for 3 months. Before and after treatment, lower extremity vascular color Doppler image, blood levels of glucose, insulin, serum matrix metalloproteinase-9 （ MMP- 9） andinterleukin- 6 （IL- 6） were measured. Results The thickness of AS plaque and that of arterial intima- media obviously reduced （P〈0. 01 and P〈0. 05）, insulin sensitivity improved noticeably （P〈0. 01 ）, and serum levels of MMP-9 and IL-6 lowered obviously （P 〈0.05） in the treatment group after treatment, but these indexes were unchanged in the control group statistically. Conclusion TMR has remarkable action in reducing the thickness of AS plaque and intima-media of artery, its mechanism might be related with improving of insulin sensitivity and anti-inflammatory reaction, and reducing of serum MMP-9 level as well in patients.