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Neurotoxicity of some MAO inhibitors in adult rat hypothalamic cell culture |
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| Authors: | Hurtado-Guzmán C Martínez-Alvarado P Dagnino-Subiabre A Paris I Caviedes P Caviedes R Cassels B K Segura-Aguilar J |
| Affiliation: | (1) Department of Pharmacodynamics, Semmelweis University, H-1445, Budapest, POB 370, Hungary;(2) Neurochemical Research Unit, Hungarian Academy of Sciences, Budapest, Hungary;(3) 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary;(4) Chemical Research Center, Hungarian Academy of Sciences, Budapest, Hungary |
| Abstract: | Monoamine oxidase-A (MAO-A) (amiflamine (AMF) and 4-methylthioamphetamine (MTA)) and MAO-B (l-deprenyl) inhibitors were found to be cytotoxic in a concentration-dependent manner for RCHT cells derived from adult rat hypothalamus. The cytotoxic effects were increased when the inhibitors were co-incubated with dicoumarol and especially with 25 μM AMF+100 μM dicoumarol (2.5-fold; P<0.001). The treatment of RCHT cells solely with AMF induced a marked decrease in the expression of DT-diaphorase mRNA. |
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