| 补肾健脾活血中药复方对D-半乳糖脑衰老小鼠海马皮质一氧化氮合酶Na+-K+-ATP酶的影响 |
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| 引用本文： | 王生福,周志强,刘栋,姜平. 补肾健脾活血中药复方对D-半乳糖脑衰老小鼠海马皮质一氧化氮合酶Na+-K+-ATP酶的影响[J]. 江苏大学学报(医学版), 2003, 13(3): 199-201 |
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| 作者姓名： | 王生福 周志强 刘栋 姜平 |
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| 作者单位： | 江苏大学医学院人体解剖学教研室,江苏,镇江,212001;南京医科大学附属医院中医科,江苏,南京,210029 |
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| 摘 要： | 目的 :研究补肾健脾活血中药复方对D 半乳糖脑衰老小鼠海马皮质一氧化氮合酶、Na+ K+ ATP酶的影响 ,探讨中药复方在延缓衰老方面的效应机制。方法 :将昆明种雄性小鼠 6 0只分为 3组 :衰老模型组 ,中药治疗组 ,空白对照组。取海马组织匀浆 ,检测一氧化氮合酶、Na+ K+ ATP酶的活性。结果 :中药治疗组与衰老模型组相比 ,海马皮质一氧化氮合酶、Na+ K+ ATP酶的活性明显升高 (P <0 .0 5 )。结论 :本研究提示补肾健脾活血中药复方通过提高一氧化氮合酶、Na+ K+ ATP酶的活性在延缓衰老方面起作用。
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| 关 键 词： | 一氧化氮合酶 Na+-K+-ATP酶 海马 小鼠 |
| 文章编号： | 1671-7783(2003)03-0199-03 |
| 修稿时间： | 2003-05-13 |
The Effect of the YSF on NOS and Na+-K+-ATPase in the Hippocampus of D-galactose Brain Aged Mice |
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| WANG Sheng fu ,ZHOU Zhi qiang ,LIU Dong ,JIANG Ping. The Effect of the YSF on NOS and Na+-K+-ATPase in the Hippocampus of D-galactose Brain Aged Mice[J]. Journal of Jiangsu University Medicine Edition, 2003, 13(3): 199-201 |
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| Authors: | WANG Sheng fu ZHOU Zhi qiang LIU Dong JIANG Ping |
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| Affiliation: | WANG Sheng fu 1,ZHOU Zhi qiang 1,LIU Dong 2,JIANG Ping 1 |
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| Abstract: | Objective: To study the effect of Jian Pi Bu Shen Hu Xue Compound Recipe (YSF) on NOS and Na + K + ATPase in D galactose brain aged mouse. Methods: Totally 60 male mice were divided into three groups: the treated group, the model group and the control group. The activities of NOS and Na + K + ATPase of the mice hippocampus in three groups were measured. Results: The activities of NOS and Na + K + ATPase of the treated group was increased markedly compared to the model group( P <0.05). Conclusion: YSF would be effective in delaying senility by increasing the activities of NOS and Na + K + ATPase of the mice hippocampus. |
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| Keywords: | NOS Na + K + ATPase Hippocampus Mouse |
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