儿童皮肤原发性肥大细胞瘤2例临床病理观察

目的 探讨皮肤原发性肥大细胞瘤(CM)的临床病理特征、免疫表型、超微结构及鉴别诊断.方法 对2例皮肤原发性肥大细胞瘤进行临床病理学观察、免疫组化及超微结构研究,并复习相关文献.结果 2例患儿均为男性,年龄为4个月和3岁,皮损位于颈部、肩部及右足跟部.镜下见真皮层多量圆形或卵圆形中等大小细胞聚集,异型性不明显,核分裂象未见.免疫组化:瘤细胞CD117(+),CD1a和S-100蛋白(-)；甲苯胺蓝染色显示胞质内出现较多紫红色异染颗粒.结论 皮肤原发性肥大细胞瘤是好发于儿童的一种少见病,明确该病变的临床病理及免疫表型特征对于诊断及鉴别诊断有重要意义.

Primary cutaneous mastocytoma:two case report and review of literature

Objective To investigate the clinicopathologic features,immunotype,differential diagnosis and ultrastructural features of primary cutaneous mastocytoma.Methods Clinicopathologic features,immunotype and ultrastructural features of two cases with primary cutaneous mastocytoma were studied and related literatures were reviewed.Results Two patients were both male.The age of them was 4 months and 3 years,respectively.The skin lesions situated on the neck,shoulder and the right heel.A dense aggregation of middle cells in the dermis was demonstrated under a microscope.These cells were round and oval in shape with no significant atypia and mitosis.The cells were immunoreactive for CD117.CD1a and S-100 were negative.Purple metach romatic granules in the cells were demonstrated by toluidine blue stain.Conclusions Cutaneous mastocytosis is a rare disease which occurs predominantly in childhood.The chinicopathologic features and immunotype are important for diagnosis and differential diagnosis.