Clinical and positron emission tomography findings of chorea associated with primary antiphospholipid antibody syndrome. |
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Authors: | Steve W Wu Brent Graham Michael J Gelfand Ralph E Gruppo Argirios Dinopolous Donald L Gilbert |
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Affiliation: | Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA. Steve.wu@cchmc.org |
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Abstract: | A fourteen-year-old right-handed male with a history of attention deficit hyperactivity disorder (ADHD) presented with alternating hemichorea. Laboratory findings included elevated anticardiolipin IgG and anti-beta(2)-glycoprotein I IgG, which were consistent with primary antiphospholipid antibody syndrome. Positron emission tomography (PET) imaging revealed altered striatal metabolism in his left putamen while he was exhibiting right-sided hemichorea. His symptoms resolved on prednisone; however, his antiphospholipid antibody profile remained markedly abnormal despite being symptom-free for 26 months. |
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Keywords: | chorea antiphospholipid antibody syndrome PET imaging steroid |
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