白介素-2联合顺铂治疗恶性心包积液的疗效观察

目的:观察白介素-2联合顺铂治疗恶性心包积液的疗效。方法:A组:白介素-2100万单位 顺铂40mg/m2 生理盐水30ml,每周1次。B组:顺铂40mg/m2 生理盐水30ml,每周1次。病人治疗3周期以上后参与疗效评价。结果:治疗30天后CR率A组为93.3%(28/30),B组为80%(24/30);90天后CR率A组为80%(24/30),B组为70%(21/30),两组无显著性差异(P>0.05);180天后CR率A组为76.67%(23/30),B组为50%(15/30),两组显著性差异(P<0.05)。结论:两组短期缓解率无明显差异,但长期完全缓解率有显著差异。

Clinical efficacy of interleukin -2 plus cisplatin in treatment of malignant hydropericardium

Objective:To evaluate the clinical efficacy and toxicity of interleukin-2 plus cisplatin in treatment of malignant hydropericardium. Methods: Group A: inject Interleukin-2 1000000U plus cisplatin 40mg/m2 into pericardy once a week. Group B: inject cisplatin 40mg/m2 into pericardy once a week. To evaluate the clinical efficacy and toxicity three weeks later. Results: After 30 days , CR was 93.3%(28/30) in group A , CR 80%(24/30)in group B;After 90 days, CR 80%(24/30) in group A, CR 70%(21/30)in group B,there was not significance of CR in 2 groups of 30 or 90 days (P>0.05). After 180 days, CR was 76.67%(23/30) in group A,CR 50%(15/30)in 2 group B,there was significance of CR in 2 groups of 180 days (P<0.05).Conclusion:There is nosignificance of CR in 2 groups of short terms,but significance of CR in 2 groups of longer terms.