糖尿病患者红细胞膜Na~ -K~ ATP酶的改变

测定了34例无并发症的非胰岛素依赖型糖尿病患者红细胞膜Na~( )-K~( )ATP酶活性,并与20例年龄相匹配的正常人作比较。结果表明糖尿病患者红细胞膜Na~( )-K~( )ATP酶活性比正常人明显降低,该酶活性与馒头餐胰岛素释放试验的最高胰岛素水平和胰岛素曲线下面积呈明显正相关,而与空腹血糖和糖化血红蛋白无明显相关。糖尿病者红细胞超氧化物歧化酶含量明显降低,但与Na~( )-K~( )ATP酶活性之间无明显相关。提示糖尿病时Na~( )-K~( )ATP酶活性受血中胰岛素水平的调节。

A Study on the Na -K ATPase Activity of Erythrocyte Membranes in Diabetic Patients

A study on the Na -K ATPase activity of erythrocyte membranes was carried out in 34 NIDDM patients without complications and in 20 age-matched normal control subjects. The Na -K ATPase activity was decreased in the NIDDM patients as compared with that of the normal subjects. There was a positive correlation between the Na -K ATPase and the serum insulin peak level as well as the area under curves of insulin releasing test. There was no correlation between the Na -K ATP ase and the fasting blood glucose or glycohemoglobin level. The mean value of erythrocyte su-peroxide dismutase (SOD) was decreased in the NIDDM patients as compared with that of normal subjects. But the Na -K ATPase activity was not correlated with SOD. The result suggests that Na -K ATPase activity in the NIDDM patients is regulated by the serum insulin level. Insulin treatment would be useful for these patients to increase the activity of Na -K ATPase and prevent chronic complications.