十一酸睾酮改善糖尿病阴茎勃起功能障碍患者对西地那非的反应

目的 探讨十一酸睾酮与西地那非联用治疗糖尿病患者阴茎勃起功能障碍的效果。方法 将80例阴茎勃起功能障碍、且经西地那非治疗无效的2型糖尿病患者，随机分为两组：A组：40例，在用西地那非治疗的同时加用十一酸睾酮（120mg／d）；B组：40例，在用西地那非治疗的同时加用维生素E（30mg／d）两组均治疗1个月。观察患者治疗前后血清睾酮水平、IIEF-5评分和阴茎海绵体血流量的变化。结果A组较治前。血清睾酮明显升高（P〈0．01），IIEF-5评分显著提高（P〈0．05），阴茎海绵体血流量明显增加（P〈0．05）；其中30例（75％）患者性交时阴茎能满意地勃起；未出现任何不良反应。B组治疗前后上述指标无明显变化（均P〉0．05）。结论 十一酸睾酮能显著改善经用西地那非治疗无效的糖尿病患者的阴茎勃起功能，且安全性好。

Testosterone undecanoate improves response to Sildenafil in diabetic patients with erectile dysfunction

Objective] To evaluate the efficacy of Testosterone undercanoate combined with Sildenafil in treating diabetic erectile dysfunction. Methods] Eighty cases of Sildenafil non-responders in type 2 diabetics with erectile dysfunction were randomized into two groups, 40 cases in each. Group A was given Testosterone undercanoate (120mg/d) combined with Sildenafil for 1 month. Whereas, group B received Vitamin E (30 mg/d) plus Sildenafil also for 1 month. Before and after the study the change of serum testosterone level, IIEF-5 score and intracavernous arterial inflow were investigated. Results] In Testosterone undercanoate treated group, the serum testosterone was markedly increased (P ＜0.01), IIEF-5 score was significantly elevated (P ＜0.05) and intracavernous arterial inflow was greatly enhanced (P ＜0.05), consequently resulting in satisfactory penile erection during coitus in 30 cases (75%). By contrast, neither of the above parameters showed any significantly change in group B (P ＞0.05). There were no untoward reactions during Testosterone undercanoate treatment. Conclusion] Testosterone undercanoate improves penile erection efficiently in the diabetic patients failing to Sildenafil alone. Testosterone undercanoate is safe and well tolerated.