微米红参对小鼠抗疲劳和耐缺氧能力的影响

[目的]探讨微米红参对脾虚小鼠耐力和抗异丙肾上腺素心肌缺氧能力的影响.[方法]通过给予利血平诱发脾虚模型和异丙肾上腺素心肌缺血模型,建立正常对照组、模型对照组、红参细粉小、大剂量组(2.5,5.0g/kg)、微米红参小、大剂量组(2.5,5.0g/kg),测定小鼠转棒时间、缺氧存活时间和耗氧量.[结果]与模型对照组比较,红参细粉小、大剂量、微米红参小、大剂量组小鼠转棒时间分别延长39.69%,92.18%,100.99%,79.39%,小鼠缺氧生存时间分别延长19.01%,30.28%,54.29%,58.35%,5～10min累计耗氧量分别减少20.94%,24.24%,21.76%,22.72%,微米红参的耐缺氧作用强于红参细粉.[结论]微米红参具有提高小鼠抗疲劳和耐缺氧能力的作用,且效果优于红参细粉.

Effects of the micron Red Ginseng on anti-fatigue and hypoxia tolerance in mice

OBJECTIVE To study the effects of micron Red Ginseng on toleration of spleen asthenia and the ability of resistance to isoproterenol-induced myocardial anoxia in mice. METHODS The spleen asthenia model was induced by reserpine and the myocardial ischemic model was induced by isoproterenol in mice, and the mice were divided into normal control group, model control group, low and high dosage groups of fine powder of the Red Ginseng（2.5 and 5.0 g/kg）, low and high dosage groups of the micron Red Ginseng （2.5 and 5.0 g/kg）, and it was detected in mice that the time of rolling stick, the survival time of anoxia and the oxygen consumption. RESULTS Compared with the model control group, the time of rolling stick in the low and high dosage groups of fine powder of the Red Ginseng and low and high dosage groups of the micron Red Ginseng were prolonged 39.69%, 92.18%, 100.99% and 79.39%, respectively, and the survival time of anoxia were prolonged 19.01%, 30.28%, 54.29% and 58. 35%, respectively, and the accmulation oxygen consumption of 5-10 rain were decreased 20.94%, 24.24%, 21.76% and 22.72%, and the function of anti-hypoxia of micron Red Ginseng was stronger than that of fine powder of the Red Ginseng. CONCLUSION The micron Red Ginseng has the effects of improving the anti-fatigue and anti-hypoxia ability in mice, and is better than fine powder of the Red Ginseng.