喹硫平和氟哌啶醇治疗老年痴呆精神行为症状的对照研究

目的：观察喹硫平和氟哌啶醇治疗老年痴呆精神行为症状的疗效和安全性。方法：采用随机对照研究,喹硫平组28例,剂量(130±s 60)mg·d~(-1),25～400mg·d~(-1),氟哌啶醇组23例,剂量(4．8±1．4)mg·d~(-1),2～20mg·d~(-1),疗程12wk,治疗前后采用痴呆病理分析评定量表(BEHAVE-AD)和治疗时出现的症状量表(TESS)评定疗效和不良反应。结果：2组病人治疗后BEHAVE-AD评分显著下降(P＜0．01),2组病人之间治疗前后BEHANE-AD的减分值无显著差异(P＞0．05),氟哌啶醇组44%有锥体外系反应,明显高于喹硫平组的7%,有显著差异(P＜0．05)。结论：喹硫平和氟哌啶醇治疗老年痴呆精神行为症状疗效确切,喹硫平不良反应少。

Quetiapine vs haloperidol in behavioral and psychological symptoms of dementia in age

AIM:To assess the efficacy and safety of quetiapine and haloperidol in the treatment of behav- ioral and psychological symptoms of dementia(BPSD).METHODS:A randomized comparative study was car- ried out for 28 patients of quetiapine group which were treated with quetiapine(130±s60)mg·d~(-1),25-400mg·d~(-1),individually;and 23 patients of haloperidol group receivid haloperidol(4.8±1.4)mg·d~(-1),2-20 mg.d~(-1), individually;with a course of 12 wk.BEHAVE-AD was used for the patbogenesis analysis of denmentia before and after treatment.TESS was taken for the evaluation of the efficacy and adverse reactions during treatment. RESULTS:After 12 wk treatment,the scores of BEHAVE-AD of patients in both groups were significantly re- duced(P＜0.01)but no significant difference between them(P＞0.05).The incidence of EPS was 7 % in quetiapine group,which was significantly lower than 44 % in haloperidol group(P＜0.05).CONCLUSION: Quetiapine and haloperidol show good efficacy for treating BPSD.Quetiapine is better with less adverse reaction.