Comparative analysis of neuroprotective activity of new chemical agent Vp and piracetam |
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| Authors: | Yu V Burov A B Uzdenskii T N Robakidze |
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| Institution: | (1) Research Center for Safety of Bioactive Compounds, Starya Kupavna, Moscow Region;(2) Institute of Neurocybernetics, Rostov State University, Rostov-on-Don |
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| Abstract: | The effect of new agent Vp (9-butylamine-3,3-dimethyl-3,4-dihydroacridine-1(2H) hydrochloride) on lifetime of isolated mechanoreceptive
crayfish neurons was evaluated by the duration of its impulse activity. Vp significantly and dose-dependently prolonged the
lifetime of both spontaneously degrading neurons and neurons degrading under conditions of inhibition of various stages of
the energy metabolism: glycolysis and oxidative phosphorylation. The effect of Vp in a concentration of 10−7 M surpassed that of amiridine. Piracetam also prolonged the lifetime of spontaneously degrading neurons, but only in very
high concentration (10−2 M). It is concluded that Vp possesses a neuroprotective activity.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 4, pp. 430–433, April, 2000 |
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| Keywords: | aminoacridine derivatives piracetam mechanoreceptive crayfish neurons potential effects |
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