Trophic effect of angiotensin II, vasopressin and oxytocin on the ventral spinal cord of rat embryo |
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Authors: | Y Iwasaki M Kinoshita K Ikeda K Takamiya T Shiojima |
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Affiliation: | Fourth Department of Internal Medicine, Toho University Ohashi Hospital. |
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Abstract: | We studied trophic effects of angiotensin II, vasopressin and oxytocin on explanted ventral spinal cord cultures derived from 13 to 14-old day rat embryos. There was a significant neurite promoting effect in angiotensin II and vasopressin-treated cultures. Angiotensin II had the most potent effect at any concentrations. It became clear that minimum effective concentration was 10(-8)M in both angiotensin II and vasopressin. However, oxytocin had no neurotrophic effect at any concentrations. Our results demonstrated that angiotensin II and vasopressin have a neurotrophic effect on ventral spinal cord in cultures, and may contribute to therapeutic strategy of amyotrophic lateral sclerosis. |
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