| 5-Fu缓释剂局部埋植治疗卵巢癌腹膜后转移的实验研究 |
| |
| 引用本文： | 陈峥峥,凌斌,赵卫东,王世亮,王群华,周颖,陈纲,许恬怡,姚凤球. 5-Fu缓释剂局部埋植治疗卵巢癌腹膜后转移的实验研究[J]. 安徽医科大学学报, 2005, 40(6): 538-540 |
| |
| 作者姓名： | 陈峥峥 凌斌 赵卫东 王世亮 王群华 周颖 陈纲 许恬怡 姚凤球 |
| |
| 作者单位： | 安徽医科大学附属省立医院妇产科、安徽分子医学重点实验室,合肥,230022;安徽医科大学附属省立医院妇产科、安徽分子医学重点实验室,合肥,230022;中国福利会国际和平妇幼保健院,上海,200030;合肥工业大学控释药物研究室,合肥,230001 |
| |
| 基金项目： | 安徽省自然科学基金资助项目（编号：20050430701） |
| |
| 摘 要： | 目的探讨植入用5Fu缓释剂局部埋植化疗用于治疗卵巢癌腹膜后转移的可行性。方法建立卵巢癌腹膜后转移动物模型,随机分成三组,腹膜后局部埋植组(A组)埋植5Fu缓释剂2mg,腹腔给药组(B组)注射同等剂量的氟尿嘧啶针剂,空白对照组(C组)腹腔注射生理盐水,观察肿瘤的生物学行为和治疗效果。结果A组较B、C组瘤体积明显减小,重量减轻,荷瘤鼠生存状态提高。结论腹膜后局部埋植5Fu缓释剂对卵巢癌腹膜后转移具有明显的治疗效果,为临床治疗卵巢癌腹膜后转移提供了一种新的治疗方法。
|
| 关 键 词： | 氟尿嘧啶/治疗应用 卵巢肿瘤/迟效制剂 药物疗法 腹膜后肿瘤/继发性 |
| 文章编号： | 1000-1492(2005)06-0538-03 |
| 收稿时间： | 2005-06-01 |
| 修稿时间： | 2005-07-19 |
Experimental study of 5-fluorouracil sustained-release pellet in the treatment of retroperitoneal metastasis of ovarian cancer |
| |
| Chen Zhengzheng, Ling Bin, Wang Qunhua et al. Experimental study of 5-fluorouracil sustained-release pellet in the treatment of retroperitoneal metastasis of ovarian cancer[J]. Acta Universitis Medicinalis Anhui, 2005, 40(6): 538-540 |
| |
| Authors: | Chen Zhengzheng Ling Bin Wang Qunhua et al |
| |
| Affiliation: | Dept of Obstetrics and Gynecology of Anhui Provincial Hospital ,Anhui Medical University, Hefei 230001 |
| |
| Abstract: | Objective To investigate the feasibility of chemothreapy by 5-fluorouracil (5-Fu) sustained-release pellet on retroperitoneal metastasis of ovarian cancer. Methods We first established the retroperitoneal metastasis models of human ovarian cancer. Thirty-nine mice were divided into 3 groups: 5-Fu(2 mg) local implant group,5-Fu intraperitoneal injection group and NS injection group. Two weeks later, therapeutic efficacy in the three groups was evaluated. Results The therapeutic efficacy was significantly improved in 5-Fu local implant group than the other two groups(P<0.05).And the survival state of SCID mice was improved. Conclusion The slow-released 5-Fu pellet in the treatment of ovarian cancer is feasible. And it may provide a new therapy strategy for retroperitoneal metastasis of ovarian cancer. |
| |
| Keywords: | fluorouracil/therapeutic use ovarian neoplasms/drug therapy retroperitoneal neoplasma secondary delayed-action preparation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
