| 染料木素对骨代谢和脂代谢的研究新进展 |
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| 引用本文： | 朱文清,邹娜,杨亚东,刘训志,黄志华. 染料木素对骨代谢和脂代谢的研究新进展[J]. 中国骨质疏松杂志, 2014, 0(8): 978-981 |
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| 作者姓名： | 朱文清 邹娜 杨亚东 刘训志 黄志华 |
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| 作者单位： | 赣南医学院第一附属医院骨科;赣县人民医院;赣南医学院科研中心; |
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| 基金项目： | 赣南医学院校级2012课题(YB20121) |
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| 摘 要： | 染料木素是豆科植物提取的活性成分,它能明显降低恶性肿瘤发生,能够通过不同的传导途径促进成骨细胞生成,增加骨的碱性磷酸酶活性以及骨DNA和钙的含量,并抑制破骨细胞分化,达到防止骨质减少,抗骨质疏松的作用。染料木素同时可以促进血脂代谢,防止内脂质的氧化作用,软化血管,达到保护心脑血管,防止心脑血管意外的作用。随着对其作用机制研究的不断深入,必将开发出一系列相关药品,最终为人类健康造福。
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| 关 键 词： | 染料木素 骨质疏松症 骨代谢 脂代谢 |
| 收稿时间： | 2013-09-01 |
Research progress of genistein on bone metabolism and lipid metabolism |
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| ZHU Wenqing,ZOU N,YANG Yadong,LIU Xunzhi and HUANG Zhihua. Research progress of genistein on bone metabolism and lipid metabolism[J]. Chinese Journal of Osteoporosis, 2014, 0(8): 978-981 |
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| Authors: | ZHU Wenqing ZOU N YANG Yadong LIU Xunzhi HUANG Zhihua |
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| Affiliation: | Department of Orthopedics, the First Affiliated Hospital of Gannan Medical College, Ganzhou 341000;People''s Hospital, Ganxian 341100;Scientific Research Center of Gannan School of Medicine, Ganzhou 341000, China |
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| Abstract: | Genistein is a kind of active ingredients extracted from leguminous plants.It can significantly reduce the incidence of malignant tumors, promote bone formation through different signaling pathways, increase bone alkaline phosphatase activity and bone DNA and calcium content, and inhibit osteoclast differentiation, which can prevent the occurrence of osteopenia and osteoporosis.Genistein also can promote lipid metabolism, prevent lipid oxidation, soften the blood vessels, which can protect the cardiovascular and prevent cardiocerebral vascular accident.With the thorough research on its mechanism, a series of related drugs will be developed ultimately for human health benefits. |
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| Keywords: | Genistein Osteoporosis Bone metabolism Lipid metabolism |
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