灵芝孢子粉对大鼠心肌缺血脂质过氧化损伤的影响

目的观察灵芝孢子粉对心肌缺血大鼠的干预作用及抗氧化损伤的药物疗效。方法将30只Wistar大鼠随机分为对照组、模型组及灵芝孢子粉治疗组，雌雄各半。对照组：常规饲养，不做其他处置。模型组：同对照组常规饲养3周后，行左冠状动脉前降支结扎建立心肌缺血模型后继续饲养1周。治疗组：灵芝孢子粉按2．5g／kg灌胃给药3周，再行左冠状动脉前降支结扎建立心肌缺血模型后，继续给药1周。动物处死取材后，观察心肌梗死面积，血清MDA含量及SOD活性变化。结果灵芝孢子粉治疗组明显缩小心肌梗死区面积，降低血清MDA含量，提高血清SOD活性。结论灵芝孢子粉对大鼠实验性心肌缺血具有保护性作用，其机制可能通过降低脂质过氧化损伤有关。

Effect of lucid ganoderma spores power on Anti-lipid peroxidative damage induced by the myocardial ischemia in rats

Objective To observe the effects of lucid ganoderma spores power on myocardial ischemia in rats and anti-lipid peroxidative damage. Methods Thirty healthy wistar rats were divided randomly into three groups： control group,model group and cure group （2.Sg/kg）,with half female and half male rats in each group.Model group and cure group was established by ligating anterior descending coronary artery.Lucid ganoderma spores power was administered for three weeks prior to the operation and a week after the operation in cure group.Rats were sacrificed a week after ligation.Blood was collected for detecting the changes of MDA,SOD and myocardial infarction area was determined by using 2,3,5-triphenyhetrazolium chloride （TTC） staining. Results Lucid ganoderma spores power can reduced significantly the infarct areas,and decrease the levels of MDA and SOD activity in serum of rats. Conclusion Lucid Ganoderma spores power has a protective effect on experimental myocardial ischemia in rats,which might be related to the anti-lipid peroxidation injury.