血清脂肪细胞脂肪酸结合蛋白与2型糖尿病大血管病变的相关性研究

目的 探讨T2DM患者血清脂肪细胞脂肪酸结合蛋白（A-FABP）水平与大血管病变的相关性. 方法 选取60例T2DM患者,其中未合并大血管病变患者（A组）30例、合并大血管病变患者（B组）30例,另选取我院同期30名健康体检者为正常对照（NC）组.采用ELISA检测3组血清A-FABP水平,并进行比较. 结果 3组血清A-FABP水平依次为：NC组（9.66±2.15） ng/L＜A组（19.05±3.82）ng/L＜B组（36.42±8.04）ng/L;A组血清A-FABP水平与FPG、2 hPG、TC相关（r值分别为0.478、0.453、-0.387,P＜0.05或P＜0.01）.B组血清A-FABP水平与FPG、2 hPG、HbA1c、SBP、TG、HDL-C相关（r值分别为0.388、0.408、0.380、0.435、-0.378、-0.390,P＜0.05或P＜0.01）.回归分析显示,校正混杂因素后,血清A-FABP水平仍与糖尿病大血管病变相关（P＜0.05）. 结论 血清A-FABP是糖尿病合并大血管病变的独立危险因素之一,对预测T2DM合并大血管并发症有一定的意义.

The correlation between serum adipocyte fatty acid-binding protein and macroangiopathy in patients with type 2 diabetes mellitus

Objective To explore the association between serum adipocyte fatty acid-binding protein （A-FABP） level and macroangiopathy in patients with T2DM. Methods 60 patients with T2DM were divided into two groups： T2DM without （group A, n = 30） and with （group B, n= 30） macroangiopathy. 30 healthy people who received healthy examination were selected as control group （NC group）. ELISA was used to detect the serum A-FABP level. Results The serum levels o{ A-FABP in three groups were in order as following：NC group （9.66±2. 15） ng/L],group A E（19. 05±3. 82） ng/L],group B （36.42± 8. 04） ng/L]. In group A, the serum A-FABP level was positively correlated with FPG and 2 hPG（r= 0. 478,0. 453, respectively, P〈0.05 or P〈 0.01 ）, and negatively correlated with TC （r = - 0.387, P〈 0.05）. In group B, the serum A-FABP level was positively correlated with FPG, 2 hPG, HbA1 c and SBP （r=0.388,0.408,0.380 and 0.435,respectively,P〈0.05 or P〈0.01） ,and negatively correlated with TG and HDL-C （r=-0. 378,-0. 390, P〈0.05）. Logistic regression analysis showed that serum A-FABP level was independently related to macrovaseular complications of diabetes after removing the confounding factors （P〈0.05）. Conclusion Serum A-FABP is one of the independent risk factors for diabetes mellitus,and can serve as a biomarker to predict the early vascular complications in patients with T2DM.