泸州地区妇女HPV感染与宫颈病变程度的关系

目的分析泸州地区妇女不同宫颈病变程度与人乳头瘤病毒（HPV）感染的关系。方法采用基因芯片技术对泸州地区783例妇女不同程度宫颈病变样本分为慢性宫颈炎、CINI、CINII、CINⅢ、乳头状瘤及宫颈癌6组，并行HPV基因分型检测。结果783例宫颈病变样本的总感染率为54．79％（429／783），其中宫颈癌感染率84．07％（95／113），显著高于其余各组（P〈0．05）；慢性宫颈炎感染率为42．21％（168／398），显著低于除CINI组以外的各组（P〈0．05）；乳头状瘤组感染率79．31％（23／29），显著高于慢性宫颈炎及CINI组（P〈0．05）。429例阳性患者样本中，高危感染率80．89％（374／429），其中乳头状瘤组感染率显著低于其余各组（P〈0．05），宫颈癌感染率显著高于其余各组（P〈O．05）。HPV阳性患者亚型分布中，仅高危型感染者乳头瘤样病变感染率显著低于其余各组（P〈0．05），仅低危感染者乳头状瘤感染率显著高于其余各组（P〈0．05）。结论泸州地区宫颈病变妇女高危HPV感染与宫颈癌及宫颈上皮内瘤变有关，并有随宫颈病变程度加重而升高的趋势。低危HPV感染为尖锐湿疣等良性性传播疾病的主要病原因子。

Correlation between HPV infection-and cervical lesions in Luzhou area

Objective To fight against cervical cancer,we investigated the relationship between human papilloma virus （HPV） infection and women with cervical disease in Luzhou area. Methods A total of 783 samples of women with cervical disease were divided into 6 groups（Including chronic cervicitis,CIN I ,CIN lI ,CIN ~ ,Papilloma and carcinoma groups）,and were tested by HPV genotyping technology. Results The total infection rate of HPV was 54.79% （429/783）. HPV prevalence was 84.07%（95/113） in Cervical cancer group,and was significantly higher than all the other groups（P -~ 0.05）. HPV prevalence was 42.21%（168/398） in chronic cervicitis group,and significantly lower than the other groups except CIN I （P 〈 0.05）. Papilloma group infection rate was 79.31% （23/29）,significantly higher than the groups of chronic cervicitis and CINI group（P 〈 0.05）. In the total of 429 HPV positive samples,80.89%（347/429） were infected by high-risk HPV subtypes, in which,papilloma infection rate was significantly lower from other groups（P 〈 0.05）,cervical cancer infection rate was significantly higher from groups （P 〈 0.05）. Only HR-HPV infection rate in the papilloma group was significantly lower from other groups （P 〈 0.05）,but significantly higher from other groups（P 〈 0.05） with only LR-HPV infection ones（P 〈 0.05）. Conclusion HR-HPV infection rate is positively associated with different levels of cervical pathological changes in Luzhou area. The LR-HPV infection is the major risk factor for the cervix papilloma.